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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOPEY2 All Species: 11.52
Human Site: S677 Identified Species: 19.49
UniProt: Q9Y3R5 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y3R5 NP_005119.2 2298 258184 S677 S L A A N D S S R K N S W E P
Chimpanzee Pan troglodytes XP_531552 2298 258112 S677 S L A A N D S S R K N S W E P
Rhesus Macaque Macaca mulatta XP_001084653 2286 256620 S665 S L A A E D C S R K N S W E P
Dog Lupus familis XP_544874 2297 257913 D677 C A A G S D S D R K N P W D A
Cat Felis silvestris
Mouse Mus musculus Q3UHQ6 2295 257491 K677 S T E H P G R K S S W D P K P
Rat Rattus norvegicus XP_001055500 2294 257490 K676 S T E H S G R K S S W E P K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512569 2247 251024 K677 A P E D S A K K R S S W E A K
Chicken Gallus gallus XP_001232723 2283 257889 S675 Y R L S E S A S K K K I A K Q
Frog Xenopus laevis Q642P2 2270 256829 Q673 T K K R G S W Q P K Q I T G P
Zebra Danio Brachydanio rerio NP_956904 817 86774
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster A1ZBE8 2599 291169 E700 T P Q F Q L D E E S R A T Q Q
Honey Bee Apis mellifera XP_395999 2434 273219 I664 K Q S S K N S I M G S T G S L
Nematode Worm Caenorhab. elegans Q9XW10 2417 267134 Y754 H R P H D D F Y D E M T H V L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q03921 1698 194669 L164 I R P L I S S L L P G I D D E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 94.8 89.9 N.A. 86.4 86.4 N.A. 73.9 75.2 69 21.9 N.A. 27.6 32.1 22.3 N.A.
Protein Similarity: 100 99.7 96 94.6 N.A. 92.4 92.5 N.A. 83 85.4 82 28.7 N.A. 47 53.2 40.9 N.A.
P-Site Identity: 100 100 86.6 46.6 N.A. 13.3 13.3 N.A. 6.6 13.3 13.3 0 N.A. 0 6.6 6.6 N.A.
P-Site Similarity: 100 100 86.6 60 N.A. 20 26.6 N.A. 26.6 40 20 0 N.A. 20 40 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 37.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 29 22 0 8 8 0 0 0 0 8 8 8 8 % A
% Cys: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 8 36 8 8 8 0 0 8 8 15 0 % D
% Glu: 0 0 22 0 15 0 0 8 8 8 0 8 8 22 8 % E
% Phe: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 8 15 0 0 0 8 8 0 8 8 0 % G
% His: 8 0 0 22 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 8 0 0 0 8 0 0 8 0 0 0 22 0 0 0 % I
% Lys: 8 8 8 0 8 0 8 22 8 43 8 0 0 22 8 % K
% Leu: 0 22 8 8 0 8 0 8 8 0 0 0 0 0 15 % L
% Met: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 15 8 0 0 0 0 29 0 0 0 0 % N
% Pro: 0 15 15 0 8 0 0 0 8 8 0 8 15 0 43 % P
% Gln: 0 8 8 0 8 0 0 8 0 0 8 0 0 8 15 % Q
% Arg: 0 22 0 8 0 0 15 0 36 0 8 0 0 0 0 % R
% Ser: 36 0 8 15 22 22 36 29 15 29 15 22 0 8 0 % S
% Thr: 15 15 0 0 0 0 0 0 0 0 0 15 15 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 15 8 29 0 0 % W
% Tyr: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _